National News

Personalized cancer vaccine shows positive late-stage trial results

Trump chooses White House adviser Heidi Overton for FDA

National Politics

Student loan payments rise as new push in Washington targets interest rates

National Politics

Trump halts new tariffs on Canadian goods hours before deadline

Dont Waste Your Money

Small business owner loses $15,000 to fraudulent bank call

National Politics

Peltola, Sullivan trade sharp criticism as Alaska Senate race intensifies

Weather

Autumn's Forecast: Partly cloudy, cooler and patchy fog tonight

Southtowns

'Just a blessing': Cheektowaga bakery now serving Bills fans at Highmark Stadium

National Politics

Ryan Elijah ousts troubled Rep. Cory Mills in Florida's 7th District primary

Northtowns

Kenmore residents asked to help Village’s future through new comprehensive plan

National News

Was Lindsay Clancy in her right mind? Key question is now central to her trial

National Politics

US Rep Byron Donalds wins GOP nod for governor in Florida

National Politics

Border Patrol detains Padres minor league coach; family says he's in US legally

Buffalo

WUFO gives away 300 backpacks to help Buffalo families

Local News

SUNY Reconnect expands in second year, adding programs

National News

New suit against Meta and Instagram alleges the platforms are designed to addict

Niagara County

DOT begins $5.5M transformation of Lockport’s South Transit Street

Buffalo

Buffalo outer harbor slip to become coastal wetland

National Politics

Yang: Your data is worth billions and Americans are seeing none of it

Southtowns

Special Olympics athletes get a special seat for Bills open practice

National News

Woman accused of plotting to kill Treasury secretary gets 6 years in prison

National News

Lindsay Clancy's former mother-in-law said she was 'begging for help'

Scripps News Life

Navigating Europe's low river levels: What river cruise travelers need to know

National News

Frank Beard, drummer of boogie-rock trio ZZ Top, dies at 77

National Politics

Trump's crypto company gets controversial approval to start its own bank

National News

Minnesota sues Texas to force extradition of ICE agent accused in shooting

Scripps News Life

Pokémon-themed doughnuts arrive at Krispy Kreme for 30th anniversary celebration

Local News

NYSDEC and EPA expanding radiological assessments into southtowns of Erie County

National News

Penn State frat pledges were made to cut cocaine for drug ring, authorities say

Scripps News Life

FDA elevates egg recall to highest risk level over salmonella concerns

National News

ESPN co-founder Bill Rasmussen dies from the effects of Parkinson’s disease

National News

US kindergarten vaccine exemptions hit record high as immunization rates slip

National Politics

Andrew Yang proposes $15K for families as AI transforms US economy

Buffalo Bills

Here's what Buffalo Bills players think about their new grass field

National Politics

Interactive: Is the American dream still within reach for young Americans?

Scripps News Life

Outshine frozen fruit bars recalled because they may contain glass fragments

Local News

Motorcyclist killed in crash on Clinton Street in Elma

Local News

Man dies from injuries after tractor-trailer crash on I-90 in Chautauqua County

National Politics

Most drivers think driving 10 mph over posted speed limits is normal, AAA finds

National News

Disney sues FCC over challenge to broadcast licenses, claiming retaliation

Iran War

Trump says no talks planned with Iran after 60-day ceasefire deal expires

National Politics

Trump casts Florida ballot by mail after calling for limits on mail voting

Iran War

Iran closes Strait of Hormuz as diesel prices surge nationwide

National Politics

Florida primaries could shape Trump’s influence ahead of November

Sports

Lakers ownership drama: Jeanie Buss challenges siblings’ sale plan

Weather

Autumn's Forecast: Humidity and rain chances return Wednesday

National Politics

Young Americans redefine the American dream as costs rise and priorities shift 

Iran War

Trump threatens Oman as it works with Iran on a Strait of Hormuz deal

Buffalo

Shea’s expansion takes shape, boosting Buffalo’s Theater District

Local News

Disgraced former WNY Congressman running in Florida

National Politics

Lawmakers demand answers from ICE as they investigate fatal Maine shooting

Buffalo

Lawmakers concerned taxpayer funds tied to nonprofit employed defrocked priest

Northtowns

Amherst community honors fallen soldier with annual memorial motorcycle ride

Chautauqua County

Lawmakers seek buyout for WNY grape growers stranded by contract cancellations

Niagara County

Seneca Niagara Resort kicks off $47M renovation project

National News

Union leader talks about ‘missteps’ in Nancy Guthrie kidnapping

National News

Family testifies about Lindsay Clancy's declining mental state

Local News

Safire nursing homes to pay $9M to resolve fraudulent billing allegations

National News

Luigi Mangione's state murder trial postponed amid double jeopardy challenge

Local News

Five people charged after alleged assault of a BPD officer on Niagara Street