The Raiders scored 29 unanswered points in the second half to rally past and beat the Bills 38-24 on Sunday.
If that wasn't enough, according the New York Times Playoff Simulator, with all the results on Sunday, including the loss, Buffalo's chances of making the playoffs dipped to five percent.
Buffalo's current 16-year postseason drought is the longest in the NFL.
Here's a look at how Twitter reacted to the Bills Week 13 meltdown in Oakland.
— Joe Buscaglia (@JoeBuscaglia) December 4, 2016
— store716 (@store716) December 5, 2016
— Nick Filipowski (@NICK_WKBW) December 5, 2016
— Hannah Buehler (@HannahBuehler) December 4, 2016
— Nick Filipowski (@NICK_WKBW) December 4, 2016
— Eric Hellwig (@Coach_Hellwig) December 5, 2016
@NICK_WKBW not trying to be a Debbie downer but we totally gave up I know its buffalo but how do I just stop playing
— jakefromstatefarm828 (@jakedjohnson177) December 5, 2016
— Nate (@ngerst348) December 5, 2016
— YardsPerPass.com (@YardsPerPass) December 5, 2016
Time to sleep Bills fans, your season is over pic.twitter.com/xIaWGOuVkc
— SB Nation GIF (@SBNationGIF) December 5, 2016
#Bills blow a game they needed after having all the momentum. Haven't we heard that before?
— Justin Arbogast (@NFLGuy_SK) December 5, 2016
— Dave (@Billsfan4life3) December 5, 2016
The #Bills totally collapsed today. Game was there for the taking but offense, defense, and special teams all stopped producing.
— Buffalo Rumblings (@BuffRumblings) December 5, 2016