The Raiders scored 29 unanswered points in the second half to rally past and beat the Bills 38-24 on Sunday.
If that wasn't enough, according the New York Times Playoff Simulator, with all the results on Sunday, including the loss, Buffalo's chances of making the playoffs dipped to five percent.
Buffalo's current 16-year postseason drought is the longest in the NFL.
Here's a look at how Twitter reacted to the Bills Week 13 meltdown in Oakland.
— Joe Buscaglia (@JoeBuscaglia) December 4, 2016
It's a terrible terrible disease.https://t.co/meiVtwCFPD pic.twitter.com/klohr7DJtk
— store716 (@store716) December 5, 2016
Here's a LIVE look at the #Bills postseason drought #BUFvsOAK pic.twitter.com/uMfImJGDyY
— Nick Filipowski (@NICK_WKBW) December 5, 2016
Live look at #Bills fans right now. pic.twitter.com/GLESsOZz2D
— Hannah Buehler (@HannahBuehler) December 4, 2016
#Bills are imploding pic.twitter.com/t5meDTJJkX
— Nick Filipowski (@NICK_WKBW) December 4, 2016
Thank you, @52Mack_ , for putting #Bills fans out of our misery. We can now be #Raiders fans for the rest of the season. #GoBulls https://t.co/WggPCi5yMM
— Eric Hellwig (@Coach_Hellwig) December 5, 2016
@NICK_WKBW not trying to be a Debbie downer but we totally gave up I know its buffalo but how do I just stop playing
— jakefromstatefarm828 (@jakedjohnson177) December 5, 2016
@HannahBuehler @NICK_WKBW I remember my Walkman...anyone else? Unreal 17 years!
— Nate (@ngerst348) December 5, 2016
#InTheHunt pic.twitter.com/4edqNR5pwQ
— YardsPerPass.com (@YardsPerPass) December 5, 2016
Time to sleep Bills fans, your season is over pic.twitter.com/xIaWGOuVkc
— SB Nation GIF (@SBNationGIF) December 5, 2016
#Bills blow a game they needed after having all the momentum. Haven't we heard that before?
— Justin Arbogast (@NFLGuy_SK) December 5, 2016
I'd rather set the NFL record for most turnovers in a year if it meant playoffs for once. Take chances!! #bills #17YearsAndCounting
— Dave (@Billsfan4life3) December 5, 2016
The #Bills totally collapsed today. Game was there for the taking but offense, defense, and special teams all stopped producing.
— Buffalo Rumblings (@BuffRumblings) December 5, 2016