A woman, whose name has not been released, was flown to Erie County Medical Center overnight Tuesday.
Genesee County Sheriff's investigators say the woman crashed on Route 77, near Indian Falls Road. That's right near the Pembroke exit off the Thruway.
The airbags were deployed after the pick-up crashed in a ditch.
While going through the woman's truck, deputies found a pill bottle. It's unclear if that's connected to the crash.
The cause of the crash remains under investigation.