On Tuesday, Mayor Byron Brown addressed what he called a "spike in violence" over the weekend. Four shootings on New Year's Day left one man in critical condition and three other people dead.
Buffalo Police said the three homicides were "not random acts" and each victim was targeted.
As of Tuesday evening, police have no suspects or anybody in custody related to the three murders.
"The police are following up on leads," said Mayor Brown. "These are instances that will not be tolerated in the City of Buffalo. The police have been working very aggressively on all of these incidents to make sure that we put pressure on the individuals that are responsible."
Police say there is no indication any of the murders were connected to a call of shots fired Monday night on the city's east side.
Officers responding to that call ended up in a high speed police chase that led into downtown Buffalo. Police have arrested and charged the three men involved.
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