PEMBROKE, N.Y. (WKBW) — A deadly crash involving a tour bus has shut down all traffic on the New York State Thruway in the Pembroke area.
WATCH: Maki Becker reports from the scene with the latest information as of 3:30 p.m. on Friday
The crash occurred on Friday between exits 49 (Depew) and 48A (Pembroke).
New York State Police say there are multiple fatalities, injuries and people who are still trapped. Police say it's believed at least one child may have died.

Trooper James O'Callaghan told reporters they believe the bus lost control and flipped off the road. But he says they will review dash cam footage to see exactly what happened. The driver is reportedly alive and doing okay.
The bus had about 50 passengers on board. The passengers were mostly people of Chinese, Filipino and Indian descent. The bus was believed to be headed back to New York City after visiting Niagara Falls. Police are working with interpreters to speak with the surviving passengers.

Patients are being taken to ECMC and Strong Memorial Hospital. Helicopters are also being staged near the scene in case any of the trapped victims are still alive.
New York State Police and the New York State Thruway Authority are asking drivers to take alternate routes due to significant delays. Authorities say the vehicles that are stuck in traffic could be there for hours.

Governor Kathy Hochul says she has been briefed on the "tragic" tour bus accident.
I’ve been briefed on the tragic tour bus accident on the @NYSThruway.
— Governor Kathy Hochul (@GovKathyHochul) August 22, 2025
My team is coordinating closely with @nyspolice and local officials who are working to rescue and provide assistance to everyone involved.
ConnectLife has issued an emergency appeal for blood donations after the accident.
“Our community is facing a crisis,” said Sarah Diina, Senior Director of Communications & External Affairs at ConnectLife. “We are urging all eligible donors to act now. Blood is needed immediately to treat patients who are fighting for their lives.”
If you're interested in helping, you're asked to call 716-529-4270 or visit ConnectLifeGiveBlood.org to schedule a blood donation appointment.