LeSean McCoy ran for three scores as the Buffalo Bills won their fourth straight game, a 45-16 win over the San Francisco 49ers.
Sunday marked the first time since the 2008 season the Bills won four in a row. They started 5-1 that year.
Buffalo improved to 4-2 after losing their first two games on the year.
It’s the first time since 2011, when McCoy played for the Eagles, that he had three touchdowns in a game.
Facing former coach Chip Kelly for the first time since being traded from Philadelphia to Buffalo, McCoy ran for 106 yards in the first half and finished with 140.
Tyrod Taylor added two scores through the air, connecting with Justin Hunter and Robert Woods in the fourth quarter as the Bills opened up a 38-16 lead.
Making his first start of the season, Colin Kaepernick finished 13-for-29 with 187 yards and a touchdown.
He continued his protest by kneeling during the National Anthem.
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