UB Receives $8.2 Million Award

October 8, 2010 Updated Oct 8, 2010 at 12:13 PM EDT

By WKBW Programming

...

Credit: � University at Buffalo | Dougla

UB Receives $8.2 Million Award

October 8, 2010 Updated Oct 8, 2010 at 12:13 PM EDT

BUFFALO, N.Y. -- ( release ) The University at Buffalo has received an $8.2 million award from the National Heart, Lung and Blood Institute to administer a new round of studies that extend the Women's Health Initiative research for another five years.

The initial 40 WHI centers across the U.S. have been grouped into four
regional centers to carry out this new initiative. UB will oversee
scientific direction and the participant contacts of the Northeast
region's nine institutions.

These include Harvard University, Brown University, Albert Einstein
College of Medicine, University of Massachusetts at Worchester, Stony
Brook University, George Washington University, University of Medicine
and Dentistry of New Jersey and Medstar Health Research Institute, in
addition to UB.

Jean Wactawski-Wende, PhD, co-PI of UB's original $13 million WHI
Vanguard Center, is principal investigator on the new award.
Wactawski-Wende is professor and associate chair of the Department of Social and Preventive Medicine, School of Public Health and Health
Professions, and professor of gynecology-obstetrics, School of Medicine and Biomedical Sciences. In addition, she serves as UB's vice provost for strategic initiatives.

The WHI 2010-2015 Extension Study will fund continuing research into
many chronic diseases of aging, including cardiovascular disease,
cancer, osteoporosis, stroke and cognition, and will support new
studies focusing on predictors of healthy aging.

WHI is the largest clinical trial ever undertaken in the U.S.,
involving more than 162,000 women across the nation, including 4,000 in Buffalo. The goal of WHI is to gather essential clinical data on the
major diseases affecting women.

The WHI is interested, in particular, in studies concentrating on WHI
participants who now are over the age of 80, and underrepresented
minority women, primarily African-American and Native-American WHI
participants. The WHI represents the largest prospective cohort of
these older women in the United States.

"The impact of this new WHI extension study is going to be huge," says
Wactawski-Wende. "This work will change lives and paradigms regarding health in postmenopausal women and has, and will, continue to impact human health. The scientific discovery from WHI to date has been enormous. I expect in the next five years we will more than double the scientific discovery emanating from this study.

"Working on this science is exciting and personally rewarding," she
continues. "I expect funding for the WHI extension study to serve as a
catalyst for further research, and that many additional funded studies
will branch off of this work. We already have seen that type of
scientific outgrowth here in Buffalo."

UB Provost Satish K. Tripathi notes that since 1993 when the University
at Buffalo was designated a Vanguard Center for the Women's Health
Initiative, UB researchers have been at the national science forefront
in women's health. "This multi-million-dollar award, orchestrated and
led by Professor Wactawski-Wende, recognizes the national leadership
role that UB has demonstrated in our understanding of factors
contributing to chronic disease in older women, and how preventative
strategies and interventions can reduce this disease burden in our
communities," Tripathi says.

"Effectively, the Women's Health Initiative has impacted public health
by informing us on the balance of risks and benefits of certain
medications and health behaviors. And, as a result, today women are
making more-informed health decisions in mid-life and beyond. Moreover, the research associated with the WHI further contributes to the important work being conducted as part of the UB 2020 "Health and
Wellness Across the Life Span" strategic strength," he adds.

One purpose of this new WHI extension, which gathers the initial
research institutions into regional groups, is to promote further
collaboration between institutions and regions, points out
Wactawski-Wende. Investigators will have access to data and biological samples from across the WHI, providing opportunity to network and collaborate on studies nationally.

The other three WHI regional centers are headquartered at Stanford
University (western region), Wake Forest University (southwest region)
and Ohio State University (midwest region). The coordinating center for
the extension study has not yet been announced, but is expected to be
the Fred Hutchinson Cancer Institute in Seattle, Wash., Wactawski-Wende says.

A significant portion of the work will be conducted by researchers in
UB's School of Public Health and Health Professions. "Here at Buffalo
we have an exceptional group of investigators joining the WHI,"
Wactawski-Wende says. "These include Drs. Amy Millen, Michael LaMonte, Heather Ochs-Balcom and Matthew Bonner, all assistant professors in the Department of Social and Preventive Medicine, and Christopher Andrews from biostatistics and Lara Sucheston from Roswell Park Cancer Institute. Each of these investigators is proposing cutting edge science as part of their work on WHI."

UB's Millen already has been funded to study the relationship of
vitamin D status and chronic diseases of aging in the WHI. Lamonte has
a grant under review to study the effect of physical activity and
physical function in older women from WHI. Ochs-Balcom and Sucheston are investigating the roles of genetics in cancer and other conditions. Bonner will look at various factors influencing cancer risk.

"Many others from our region who are not funded directly on this new
award, but who will play important scientific roles, will be working on
the WHI data and proposing ancillary studies," says Wactawski-Wende.
"They have proposed many additional studies that fully exploit this
rich dataset. This is team science at its best."

More than 100,000 women from across the nation are expected to
participate in the WHI extension study, including thousands from
Buffalo and the greater Western New York region.

The major and unexpected results from the initial trial showed that
estrogen didn't reduce the risk of heart disease and increased the risk
of stroke in postmenopausal women who had a hysterectomy, and in
post-menopausal women who did not have a hysterectomy, hormone therapy increased the risk of breast cancer, heart disease and blood clots.

"The WHI findings already have had enormous impact on our understanding of factors influencing health and chronic disease in older women," says Wactawski-Wende.

"We owe these dedicated study participants our thanks for their
contributions to date, and sincere appreciation for their willingness
to continue to allow us to learn so much more from them over the next
five years."

The University at Buffalo is a premier research-intensive public
university, a flagship institution in the State University of New York
system and its largest and most comprehensive campus. UB's more than 28,000 students pursue their academic interests through more than 300 undergraduate, graduate and professional degree programs. Founded in 1846, the University at Buffalo is a member of the Association of American Universities.